A Survey of Machine Learning for Bladder Tumor Detection in Medical Imaging
DOI:
https://doi.org/10.29304/jqcsm.2026.18.22702Keywords:
Bladder Cancer deep learningAbstract
bladder cancer at an early stage and treating it successfully is extremely difficult due to its recurrence and spread. With the use of artificial intelligence and medical imaging tools to identify the disease, modern systems face many difficulties in applying them to different data sets; thus, they lack classification accuracy. Other problems with these models include a lack of spatial information and high computational complexity. On the other hand, although VIT models have shown promising results in medical image analysis, their performance still depends heavily on the quality of hyperparameter tuning, making them less efficient. This supports the early detection of bladder cancer, emphasizing the need to create a complete VIT-based system that is then enhanced in a meta-heuristic manner to increase detection accuracy while reducing computational complexity. In the Radiomics study, machine learning (ML) methods were systematically applied to identify sophisticated features and create analytical patterns for cancer classification and medical outcome prediction. Deep learning (DL) has significantly improved cancer detection, segmentation, and classification with convolutional neural networks and U-Net. Recently, vision transformer models have become well known for their ability to detect long-range connections in medical images. This proves that histological examination and magnetic resonance imaging allow for a new approach to bladder cancer treatment. Even if these different ideas have evolved, there are not enough routine tests to prove how well they work together. Based on bladder tumor detection techniques, This survey provides a systematic classification and diagnostic evaluation of current artificial intelligence, thereby emphasizing its methods, benefits, limitations, and potential directions for further investigation.
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References
A. Richters, K. K. H. Aben, and L. A. L. M. Kiemeney, “The global burden of urinary bladder cancer: an update,” World J. Urol., vol. 38, pp. 1895–1904, 2020, doi: 10.1007/s00345-019-02984-4.
H. Öztürk, “Detecting metastatic bladder cancer using 18F-fluorodeoxyglucose positron-emission tomography/computed tomography,” Cancer Res. Treat., vol. 47, pp. 834–843, 2015, doi: 10.4143/crt.2014.157.
NICE, “Bladder cancer: diagnosis and management of bladder cancer,” BJU Int., vol. 120, pp. 755–765, 2015, doi: 10.1111/bju.14045.
I. Jubber, S. Mitchell, S. Hussain, et al., “Social deprivation and bladder cancer: cause or effect for disparities in survival for affected women,” BJU Int., vol. 130, pp. 301–302, 2022, doi: 10.1111/bju.15832.
S. Chen, L. Jiang, X. Zheng, J. Shao, T. Wang, E. Zhang, et al., “Clinical use of machine learning-based pathomics signature for diagnosis and survival prediction of bladder cancer,” Cancer Sci., vol. 112, no. 7, pp. 2905–2914, 2021, doi: 10.1111/cas.14927.
I. J. Tsai, W. C. Shen, C. L. Lee, H. D. Wang, and C. Y. Lin, “Machine learning in prediction of bladder cancer on clinical laboratory data,” Diagnostics, vol. 12, no. 1, p. 203, 2022, doi: 10.3390/diagnostics12010203.
B. Wang, Z. Gong, P. Su, G. Zhen, T. Zeng, and Y. Ye, “Multi-machine learning model based on radiomics features to predict prognosis of muscle-invasive bladder cancer,” BMC Cancer, vol. 25, no. 1, p. 1116, 2025, doi: 10.1186/s12885-025-14279-6.
Z. Hasnain, J. Mason, K. Gill, G. Miranda, I. S. Gill, P. Kuhn, and P. K. Newton, “Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients,” PLoS One, vol. 14, no. 2, p. e0210976, 2019, doi: 10.1371/journal.pone.0210976.
] D. Morgante and J. Southgate, “Bladder tissue regeneration,” in Tissue Engineering Using Ceramics and Polymers, Elsevier, 2022, pp. 459–480.
M. Ferro, U. G. Falagario, B. Barone, M. Maggi, F. Crocetto, G. M. Busetto, and O. S. Tataru, “Artificial intelligence in the advanced diagnosis of bladder cancer—comprehensive literature review and future advancement,” Diagnostics, vol. 13, no. 13, p. 2308, 2023.
N. Tokuyama, A. Saito, R. Muraoka, S. Matsubara, T. Hashimoto, N. Satake, and Y. Ohno, “Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features,” Mod. Pathol., vol. 35, no. 4, pp. 533–538, 2022.
W. Nie, Y. Jiang, L. Yao, X. Zhu, A. Y. Al-Danakh, W. Liu, and D. Yang, “Prediction of bladder cancer prognosis and immune microenvironment assessment using machine learning and deep learning models,” Heliyon, vol. 10, no. 23, 2024.
P. N. Yin, K. Kc, S. Wei, Q. Yu, R. Li, A. R. Haake, and F. Cui, “Histopathological distinction of non-invasive and invasive bladder cancers using machine learning approaches,” BMC Med. Inform. Decis. Mak., vol. 20, no. 1, p. 162, 2020.
Z. Wei, X. Bai, Y. Xv, S. H. Chen, S. Yin, Y. Li, and Y. Xie, “A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study,” Insights Imaging, vol. 15, no. 1, p. 262, 2024.
Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., ... & Sánchez, C. I. (2017). A survey on deep learning in medical image analysis. Medical image analysis, 42, 60-88.
Ma, X., Zhang, Q., He, L., Liu, X., Xiao, Y., Hu, J., ... & Yu, B. (2024). Artificial intelligence application in the diagnosis and treatment of bladder cancer: advance, challenges, and opportunities. Frontiers in oncology, 14, 1487676.
M. G. Bandyk, D. R. Gopireddy, C. Lall, K. C. Balaji, and J. Dolz, “MRI and CT bladder segmentation from classical to deep learning based approaches: Current limitations and lessons,” Comput. Biol. Med., vol. 134, p. 104472, 2021.
K. Yildirim, P. G. Bozdag, M. Talo, O. Yildirim, M. Karabatak, and U. R. Acharya, “Deep learning model for automated kidney stone detection using coronal CT images,” Comput. Biol. Med., vol. 135, p. 104569, 2021.
S. Abuhasanein, L. Edenbrandt, O. Enqvist, S. Jahnson, H. Leonhardt, E. Trägårdh, and H. Kjölhede, “A novel model of artificial intelligence based automated image analysis of CT urography to identify bladder cancer in patients investigated for macroscopic hematuria,” Scand. J. Urol., vol. 59, pp. 90–97, 2024.
M. G. Bandyk, D. R. Gopireddy, C. Lall, K. C. Balaji, and J. Dolz, “Bladder segmentation based on deep learning approaches: current limitations and lessons,” arXiv preprint arXiv:2101.06498, 2021.
J. Yu, M. Xie, Y. Wang, T. Fu, X. Xu, and J. Wang, “Bladder Cancer Diagnosis with Deep Learning: A Multi-Task Framework and Online Platform,” arXiv preprint arXiv:2508.15379, 2025.
E. Shkolyar, X. Jia, T. C. Chang, D. Trivedi, K. E. Mach, M. Q.-H. Meng, L. Xing, and J. C. Liao, “Augmented Bladder Tumor Detection Using Deep Learning,” Eur. Urol., vol. 76, no. 6, pp. 714–718, 2019.
Ferro, M., Falagario, U. G., Barone, B., Maggi, M., Crocetto, F., Busetto, G. M., ... & Tataru, O. S. (2023). Artificial intelligence in the advanced diagnosis of bladder cancer-comprehensive literature review and future advancement. Diagnostics, 13(13), 2308.
Tokuyama, N., Saito, A., Muraoka, R., Matsubara, S., Hashimoto, T., Satake, N., ... & Ohno, Y. (2022). Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features. Modern Pathology, 35(4), 533-538.
Yin, P. N., Kc, K., Wei, S., Yu, Q., Li, R., Haake, A. R., ... & Cui, F. (2020). Histopathological distinction of non-invasive and invasive bladder cancers using machine learning approaches. BMC medical informatics and decision making, 20(1), 162.
Wei, Z., Bai, X., Xv, Y., Chen, S. H., Yin, S., Li, Y., ... & Xie, Y. (2024). A radiomics-based interpretable machine learning model to predict the HER2 status in bladder cancer: a multicenter study. Insights into Imaging, 15(1), 262.
Nie, W., Jiang, Y., Yao, L., Zhu, X., Al-Danakh, A. Y., Liu, W., ... & Yang, D. (2024). Prediction of bladder cancer prognosis and immune microenvironment assessment using machine learning and deep learning models. Heliyon, 10(23).
Causio, F. A., De Vita, V., Nappi, A., Sawaya, M., Rocco, B., Foschi, N., ... & Russo, P. (2024). Machine Learning Approaches for Survival Prediction in Bladder Cancer: A Single-Center Analysis of Clinical and Inflammatory Markers. medRxiv, 2024-11.
Chen, C., Zhang, J., Liu, X., Zhuang, Q., Lu, H., & Hou, J. (2024). Machine learning developed an intratumor heterogeneity signature for predicting clinical outcome and immunotherapy benefit in bladder cancer. Translational Andrology and Urology, 13(7), 1104-1117.
Sokołowski, P., Wityk, P., Cierpiak, K., Babińska, M., Graczyk, W., Krawczyk, B., ... & Szczerska, M. (2024, June). Optical method supported by machine learning for urinary tract infections discrimination and bladder cancer detection. In Optical Sensing and Detection VIII (Vol. 12999, pp. 449-452). SPIE.
Xiao, B., Lv, Y., Peng, C., Wei, Z., Xv, Q., Lv, F., ... & Xiao, M. (2025). Deep learning feature-based model for predicting lymphovascular invasion in urothelial carcinoma of bladder using CT images. Insights into Imaging, 16(1), 108.
Lee, M. C., Wang, S. Y., Pan, C. T., Chien, M. Y., Li, W. M., Xu, J. H., ... & Shiue, Y. L. (2023). Development of deep learning with RDA U-Net network for bladder cancer segmentation. Cancers, 15(4), 1343.
Jiao, P., Yang, R., Liu, Y., Fu, S., Weng, X., Chen, Z., ... & Zheng, Q. (2024). Deep learning-based computed tomography urography image analysis for prediction of HER2 status in bladder cancer. Journal of Cancer, 15(19), 6336.
Marc-Adrien, H., Nicolas, P., & Marc-Emmanuel, B. (2021, July). Combining loss functions for deep learning bladder segmentation on dynamic MRI. In 2021 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI) (pp. 1-4). IEEE.
Shih, D. H., Shih, P. L., Wu, T. W., Lee, C. X., & Shih, M. H. (2023). Distinguishing bladder cancer from cystitis patients using deep learning. Mathematics, 11(19), 4118.
Sun, Z. M. (2024). Preoperative CT-based deeplearningradiomicsmodeltopredictlymphnodemetastasisandpatientprognosisinbladdercancer: a two center study. Insights Imaging, 15(1), 21.
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